More here:
http://antioxidant-scleroderma.blogspot.com/2010/02/autoantibodies-as-predictive-tools-in.html
Nat Rev Rheumatol. 2010 Feb;6(2):112-6.
Posts Tagged ‘presence’
Autoantibodies as predictive tools in systemic sclerosis.
Monday, February 8th, 2010Cooling-induced contraction and protein tyrosine kinase activity of isolated arterioles in secondary Raynaud’s phenomenon.
Thursday, December 24th, 2009Insightful post at:
http://antioxidant-scleroderma.blogspot.com/2009/12/cooling-induced-contraction-and-protein.html
OBJECTIVE: To investigate the response of skin arterioles from control subjects and patients with scleroderma and Raynaud’s phenomenon (RP/SSc) to cooling and modulators of protein tyrosine kinase (PTK) activity. METHODS: We used the microvessel perfusion technique to characterize the response of isolated dermal arterioles (100-200 microm, outside diameter) from normal (n = 17) and RP/SSc (n = 17) subjects to cooling from 37 degrees to 31 degrees C
Diagnostic value of exhaled nitric oxide to detect interstitial lung disease in systemic sclerosis.
Saturday, December 19th, 2009Original post:
http://antioxidant-scleroderma.blogspot.com/2009/12/diagnostic-value-of-exhaled-nitric.html
BACKGROUND AND AIM: Increased alveolar concentration of nitric oxide (CA(NO)) is related to the severity of interstitial lung disease (ILD) in systemic sclerosis (SSc). However, cut-off levels of CA(NO) to rule out, or to rule in, the presence of ILD in individual patients are unknown
High Ischemia-Modified Albumin Concentration Reflects Oxidative Stress But Not Myocardial Involvement in Systemic Sclerosis
Thursday, December 3rd, 2009Great post at:
http://antioxidant-scleroderma.blogspot.com/2009/12/high-ischemia-modified-albumin.html
By Didier Borderie and Colleague Systemic sclerosis (SSc) is a connective tissue disease characterized by widespread vascular lesions and fibrosis of the skin and internal organs.
Cardiomyopathies and oxidative stress
Friday, November 27th, 2009The rest is here:
http://antioxidant-scleroderma.blogspot.com/2009/11/cardiomyopathies-and-oxidative-stress.html
By D.Romero-Alvira, E.Roche, L.Placer Cardiomyopathies are the group of diseases affecting the cardiac muscle. Although they have never been related to oxidative stress diseases, an analysis of the causes of these pathologies reveals the presence of a pro-oxidative agent or that the intracardiocytic balance between oxidation and antioxidation has been broken
Elevated plasma superoxide dismutase activity in patients with systemic sclerosis
Thursday, November 12th, 2009View post:
http://antioxidant-scleroderma.blogspot.com/2009/11/elevated-plasma-superoxide-dismutase.html
By Akimichi Morita and Colleague Injury to vessel walls, especially microvascular damage due to free radicals, has been a focus of interest concerning the pathogenesis of systemic sclerosis. Excess reactive oxygen species may induce antioxidant defenses
Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis.
Friday, October 30th, 2009Great post from:
http://antioxidant-scleroderma.blogspot.com/2009/10/lack-of-evidence-of-stimulatory.html
By Jean-François Classen and Colleague OBJECTIVE: Systemic sclerosis (SSc) is a severe connective tissue disease of unknown etiology, characterized by fibrosis of the skin and multiple internal organs. Recent findings suggested that the disease is driven by stimulatory autoantibodies to platelet-derived growth factor receptor (PDGFR), which stimulate the production of reactive oxygen species (ROS) and collagen by fibroblasts. These results opened novel avenues of research into the diagnosis and treatment of SSc
Evidence for the Role of Environmental Agents in the Initiation or Progression of Autoimmune Conditions
Friday, October 30th, 2009Continued here:
http://antioxidant-scleroderma.blogspot.com/2009/10/evidence-for-role-of-environmental.html
Abstract The concordance of autoimmune disease among identical twins is virtually always less than 50% and often in the 25-40% range.
Monocytes of Patients with Systemic Sclerosis (Scleroderma) Spontaneously Release In Vitro Increased Amounts of Superoxide Anion
Sunday, August 16th, 2009Originally posted here:
http://antioxidant-scleroderma.blogspot.com/2009/08/monocytes-of-patients-with-systemic.html
By Paola Sambo and Colleague It has been suggested that toxic oxygen free radicals can be involved in the pathogenesis of systemic sclerosis (scleroderma) (SSc). Because the cells that contribute to the generation of free radicals are not known, our aim was (i) to evaluate the ability of unmanipulated and phorbol 12-myristate 13-acetate-stimulated monocytes and polymorphonucleate neutrophils of SSc patients to generate superoxide anion (O2–); and (ii) to investigate whether the O2– produced by these cells involved the activation of nicotinamide-adenine dinucleotide diphosphate oxidase biochemical pathway. Employing the superoxide dismutase-inhibitable reduction of cytochrome c to evaluate the generation of O2–, unmanipulated monocytes of SSc patients generated more O2– than primary Raynaud’s phenomenon patients and normal control monocytes (p= 0.0001), and the release was higher in patients with diffuse cutaneous involvement and 5 y or less disease duration (p = 0.02)
Oxygen free radicals and systemic autoimmunity
Thursday, August 6th, 2009Original post:
http://antioxidant-scleroderma.blogspot.com/2009/08/oxygen-free-radicals-and-systemic.html
By H Ahsan,A Ali, and R Ali Reactive oxygen species generated during various metabolic and biochemical reactions have multifarious effects that include oxidative damage to DNA leading to various human degenerative and autoimmune diseases. The highly reactive hydroxy radical (·OH) can interact with chromatin and result in a wide range of sugar and base-derived products, DNA–protein cross-links and strand breaks