Source::
http://antioxidant-scleroderma.blogspot.com/2010/02/thrombin-induced-ccn2-expression-as.html
Scleroderma (systemic sclerosis, SSc) is a fibrotic disease for which there is no therapy. CCN2 (connective tissue growth factor, CTGF) is a marker and mediator of fibrosis. Previously, it has been shown that thrombin induces CCN2 expression in fibroblasts