Posts Tagged ‘factor-nuclear’

Natural products as a gold mine for arthritis treatment

Friday, February 5th, 2010

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http://antioxidant-scleroderma.blogspot.com/2010/02/natural-products-as-gold-mine-for.html

Arthritis , an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1?) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

Friday, February 5th, 2010

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http://antioxidant-scleroderma.blogspot.com/2010/02/potential-therapeutic-effects-of.html

Abstract Although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ago.

Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity

Friday, February 5th, 2010

Originally posted here:

http://antioxidant-scleroderma.blogspot.com/2010/02/reactive-oxygen-intermediate-induced.html

Abstract Deregulation of reactive oxygen intermediates (ROI) resulting in either too high or too low concentrations are commonly recognized to be at least in part responsible for many changes associated with aging. This article reviews ROI-dependent mechanisms critically contributing to the decline of immune function during physiologic – or premature – aging. While ROI serve important effector functions in cellular metabolism, signalling and host defence, their fine-tuned generation declines over time, and ROI-mediated damage to several cellular components and/or signalling deviations become increasingly prevalent.