Original post:
http://antioxidant-scleroderma.blogspot.com/2009/12/asbestos-and-pulmonary-fibrosis.html
Our lungs get a lot of work because they are always working to trap oxygen to give to blood as well as remove carbon dioxide from the bloodstream as waste. Thus, when something happens to our lungs, it can be hugely detrimental. A lack of oxygen can make daily life difficult, and prolonged loss of air can even cause brain damage.
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http://antioxidant-scleroderma.blogspot.com/2009/12/cancer-immune-therapy-colostrum.html
Colostrum is the first breast secretion that is provided to the newborn in during the first 24-48 hours by the mammal. It contains essential nutrients, trypsin, and protease inhibitors that protect it from destruction in the GI tract as well as numerous immune system and growth factors. Colostrum is estimated to trigger at least 50 processes in the newborn
An interesting post from:
http://antioxidant-scleroderma.blogspot.com/2009/12/immunological-effects-of-silica-and.html
By Otsuki T. and Colleague Silicosis patients (SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular, SIL sometimes complicates autoimmune diseases such as systemic scleroderma , rheumatoid arthritis (known as Caplan syndrome), and systemic lupus erythematoses
An interesting post from:
http://antioxidant-scleroderma.blogspot.com/2009/12/silica-binding-and-toxicity-in-alveolar.html
By Raymond F and Colleague Inhalation of the crystalline form of silica is associated with a variety of pathologies from acute lung inflammation to silicosis, in addition to autoimmune disorders and cancer. Basic science researchers looking at the mechanisms involved with the earliest initiators of disease are focused on how the alveolar macrophage (AM) interacts with the inhaled silica particle and the consequences of silica-induced toxicity on the cellular level. Based on experimental results, several rationales have been developed on exactly how crystalline silica particles are toxic to the macrophage cell that is functionally responsible for clearance of the foreign particle
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http://antioxidant-scleroderma.blogspot.com/2009/12/macrophage-migration-inhibitory-factor.html
By Sou-Pan Wu and Colleague Objective To investigate the potential association between functional polymorphisms in the gene for the innate mediator, macrophage migration inhibitory factor (MIF), and the clinical expression of systemic sclerosis (SSc). Methods Genomic DNA samples and clinical data were collected from the Scleroderma Family Registry and DNA Repository at the University of Texas Health Science Center at Houston
Original post:
http://antioxidant-scleroderma.blogspot.com/2009/12/role-of-cytokines-in-scleroderma-use-of.html
Scleroderma is a fibrotic condition characterized by immunological abnormalities, vascular injury, and increased accumulation of matrix proteins in the skin. Although the etiology of scleroderma has not been fully elucidated, a growing body of evidence suggests that the overproduction of extracellular matrix by activated fibroblasts results from complex interactions among endothelial cells, lymphocytes, macrophages, and fibroblasts, via a number of mediators.