Cooling-induced contraction and protein tyrosine kinase activity of isolated arterioles in secondary Raynaud’s phenomenon.

Insightful post at:

http://antioxidant-scleroderma.blogspot.com/2009/12/cooling-induced-contraction-and-protein.html

OBJECTIVE: To investigate the response of skin arterioles from control subjects and patients with scleroderma and Raynaud’s phenomenon (RP/SSc) to cooling and modulators of protein tyrosine kinase (PTK) activity. METHODS: We used the microvessel perfusion technique to characterize the response of isolated dermal arterioles (100-200 microm, outside diameter) from normal (n = 17) and RP/SSc (n = 17) subjects to cooling from 37 degrees to 31 degrees C

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